Goldenseal is a Native American medicinal plant introduced to early settlers by Cherokee Indians who used it as a wash for skin diseases, wounds, and for sore, inflamed eyes. Its roots are bright yellow, thus the name. Goldenseal root has acquired a considerable reputation as a natural antibiotic and as a remedy for various gastric and genitourinary disorders.This popular North American herb grows wild in moist mountainous woodland areas. Goldenseal's long history of use among North Americans flourished after the Civil War as it was an ingredient in many patent medicines. It has been collected to the point of near extinction. Goldenseal supplies are diminishing and most is now wildcrafted, making herbal supplements costly.